Colorado Plastic Surgery Center: Regenerative Aesthetics Backed by Advanced Surgical Expertise

Led by double board-certified plastic surgeon Dr. Nick Slenkovich, our team integrates evidence-based biologic therapies with advanced aesthetic techniques to support healing, rejuvenation, and long-term skin health. We offer PRF because it aligns with our philosophy: enhancing your appearance using methods that respect your body’s natural processes while maintaining the highest medical standards.

What Is Platelet-Rich Fibrin (PRF)?

Platelet-Rich Fibrin (PRF) is a platelet concentrate derived from your own blood. Unlike earlier platelet-based treatments, PRF is produced without anticoagulants, allowing a natural fibrin matrix to form. This matrix slowly releases growth factors over time, supporting tissue repair and regeneration.

Platelets are rich in biologically active proteins known as growth factors, which play a key role in wound healing and collagen production. According to the U.S. National Library of Medicine and peer-reviewed studies available through the National Center for Biotechnology Information (NCBI), platelet concentrates can stimulate fibroblast activity, angiogenesis (new blood vessel formation), and collagen synthesis.

PRF differs from Platelet-Rich Plasma (PRP) in that it:

  • Is spun at lower speeds
  • Contains higher concentrations of leukocytes
  • Forms a fibrin scaffold that allows for slower, sustained release of growth factors

Published research demonstrates that fibrin matrices enhance cellular migration and tissue regeneration, making PRF particularly effective for skin and hair restoration applications.

In aesthetic medicine, PRF may be used to:

  • Improve skin texture and elasticity
  • Support under-eye rejuvenation
  • Enhance microneedling results
  • Stimulate hair follicle activity

Because it is entirely autologous (from your own body), the risk of allergic reaction is minimal.

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PRF Benefits

  • Gradual, Natural-Looking Refinement: Because PRF releases growth factors over time, improvements develop subtly and progressively. Skin appears healthier and more resilient rather than artificially altered.
  • Improved Skin Quality and Density: By supporting collagen remodeling and tissue repair, PRF can help strengthen thin or crepey skin—particularly in delicate areas like the lower eyelids.
  • Enhanced Circulation and Tissue Vitality: The fibrin matrix supports microvasculature, helping improve overall skin tone and luminosity as tissue health improves.
  • Soft Tissue Support Without Overfilling: In areas like the under-eyes, PRF can provide gentle improvement in hollowing without the heaviness that sometimes occurs with traditional volumizing treatments.
  • Support for Early Hair Thinning: When used on the scalp, PRF may help create a healthier environment for existing follicles, making it especially beneficial in the early stages of hair thinning.
  • Minimal Downtime: Most patients return to normal activities quickly, making PRF a practical option for those with busy schedules.

Are You a Candidate for PRF?

You may be a candidate for PRF if you:

  • Are in overall good physical health
  • Do not have active infections, blood disorders, or clotting abnormalities
  • Are not currently taking anticoagulant medications that would interfere with platelet function (or have been medically cleared)
  • Are experiencing early-stage hair thinning rather than complete follicular loss
  • Have mild to moderate skin thinning or early tissue laxity without significant excess skin requiring surgery
  • Are a non-smoker or willing to follow pre- and post-treatment health guidelines to support healing

Why Choose Colorado Plastic Surgery Center?

Our private, state-licensed facility includes the AAAASF-accredited Surgery Center of Colorado, reflecting our commitment to rigorous safety standards. Our clinical team includes experienced registered nurses and advanced aesthetic providers who perform treatments in accordance with strict medical protocols.

Dr. Slenkovich’s background in both plastic surgery and otolaryngology provides advanced anatomical expertise, particularly in delicate areas such as the under-eyes and scalp. Every PRF treatment is performed within a medically supervised environment that prioritizes sterility and patient safety.

What to Expect Before, During, and After

Consultation

We treat every consultation as an educational conversation during which we assess:

  • Your aesthetic concerns
  • Skin or hair condition
  • Medical history
  • Treatment goals

If PRF is appropriate, we will outline the number of sessions recommended and provide transparent pricing.

Procedure

  • A small amount of blood is drawn from your arm
  • The blood is spun in a centrifuge at a controlled, low speed
  • The platelet-rich fibrin layer is isolated
  • PRF is injected or applied with microneedling to the treatment area
  • The procedure typically takes 45–60 minutes

Recovery & Results

  • Mild swelling or bruising may occur for several days
  • Most patients resume normal activities within 24–48 hours
  • Collagen remodeling begins gradually over several weeks
  • Hair restoration treatments typically require a series of sessions
  • Because PRF works through biologic regeneration, results develop progressively

Subtypes of PRF

  • Injectable PRF: Commonly used under the eyes or in facial rejuvenation.
  • PRF with Microneedling: Enhances collagen stimulation.
  • PRF for Hair Restoration: Injected into the scalp to support follicular activity.
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Alternative or Related Treatments

Depending on your needs, we may also discuss:

PRF FAQs

When will I start seeing improvement?

Initial changes, such as improved skin tone, may be noticeable within a few weeks. However, more significant improvements typically develop over 2 to 3 months as collagen remodeling continues. Treatments focused on hair often require multiple sessions before any visible thickening is observed, as with our skin treatments, which also generally require several sessions for optimal results.

How long do results last?

Results vary based on age, biology, and lifestyle factors. Many patients enjoy improvement for 6–12 months or longer. Because PRF supports tissue health rather than creating artificial volume, ongoing maintenance may help sustain results.

Is PRF painful?

Most patients tolerate PRF very well. A topical anesthetic may be used for comfort, and injections are performed with precision and care. You may feel brief pressure or mild discomfort, but the procedure is generally well-tolerated.

Are there risks or side effects?

Because PRF is derived from your own blood, allergic reactions are infrequent. However, as with any injection-based treatment, temporary side effects may include swelling, bruising, tenderness, or mild redness. Less common risks can include infection, prolonged swelling, or uneven healing, but these are minimized when the procedure is performed in a medically supervised, sterile environment by experienced providers.

Who should avoid PRF treatment?

Individuals with active infections, certain blood disorders, uncontrolled systemic illnesses, or platelet dysfunction may not be appropriate candidates. Patients undergoing chemotherapy or with significant immune compromise should be medically evaluated before considering treatment.

Will PRF replace dermal fillers?

Not necessarily. PRF improves tissue quality and supports regeneration, while fillers provide structural volume. In some cases, PRF may reduce the need for filler; in others, the two may complement each other as part of a balanced plan.

Does lifestyle affect my results?

Yes. Smoking, poor nutrition, high stress levels, and inadequate sleep can all impact healing and collagen production. Maintaining a healthy lifestyle supports optimal regenerative response and longer-lasting results.

Is PRF FDA-approved?

PRF itself is considered a minimally manipulated autologous blood product prepared at the point of care. While specific preparation systems may be FDA-cleared, platelet concentrates are generally used at the physician's discretion as part of medical practice. During your consultation, we will review all safety considerations and answer any regulatory questions you may have.

Experience Expert-Led Regenerative Care

If you’re looking for a treatment that supports your skin or hair at a cellular level—without overcorrection or unnecessary intervention—we invite you to meet with our team. Schedule your consultation at Colorado Plastic Surgery Center today.

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Nick Slenkovich

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If you are considering cosmetic surgery to improve your physical appearance and self-image, we invite you to schedule a consultation with our double board-certified Denver plastic surgeon, Dr. Nick Slenkovich. Dedicated to your comfort from your first visit to your final follow-up, the surgeon and staff of Colorado Plastic Surgery Center will always treat you with kindness and caring.

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All content on this page was medically reviewed by Double-Board-Certified Plastic Surgeon Dr. Nick Slenkovich

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